Interfacial reaggregation of ultrasonically disrupted erythrocyte membranes.
نویسندگان
چکیده
منابع مشابه
Multiscale simulation of erythrocyte membranes.
To quantitatively predict the mechanical response and mechanically induced remodeling of red blood cells, we developed a multiscale method to correlate distributions of internal stress with overall cell deformation. This method consists of three models at different length scales: in the complete cell level the membrane is modeled as two distinct layers of continuum shells using finite element m...
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Splenectomized patients with hemoglobin (Hb) Köln have rigid RBCs with membrane polypeptide aggregates that are not dissociable with disulfide-reducing agents. Malondialdehyde (MDA) action on normal RBCs produced rigid RBCs with similar nondissociable aggregates. To test the hypothesis that Hb Köln RBC aggregates contained unsaturated MDA-type bonds, we reduced normal control RBC membranes, Hb ...
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Sialic acid residues are responsible for the negative charge at the cell surface in human erythrocytes (Eylar et al., 1962), and are involved in Mand N-group specificity (Ebert & Jurgen, 1972). The sialic acid content decreases as erythrocytes age (Balduini et al., 1974; Baxter & Beeley, 1975), and its role as a determinant of the erythrocyte lifespan is described in several reports (Jancik & S...
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Two new vascular smooth muscle relaxants, bepridil and cetiedil, were found to possess specific CaM-inhibitory properties which resembled those of trifluoperazine. Trifluoperazine, bepridil, and cetiedil inhibited Ca2+-dependent '251-CaM binding to erythrocyte membranes and CaM activation of membrane Ca2+-ATPase with IC50 values of -12, 17, and -40 MAM, respectively. This does not appear to be ...
متن کاملThe Interaction of Phosphofiuctokinase with Erythrocyte Membranes*
The interaction of muscle phosphofructokinase with human erythrocyte ghost membranes was investigated. Scatchard analysis of the binding reveals only a single class of binding sites numbering approximately 4 x 10” sites/ghost with an association constant of 2 X lo7 M-‘. Maximum binding is observed below pH 6.8 and is complete within 30 min at 4”, 24”, and 37°C; binding is inhibited by high ioni...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1968
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.60.2.614